Intracranial foreign body granuloma caused by oxidized cellulose polymer and etherified sodium carboxymethyl cellulose: an experimental study with orictolagus cuniculus rabbits
Keywords:
etherified sodium carboxymethyl cellulose, granuloma, oryctolagus cuniculus rabbits, oxidized cellulose polymer, topical hemostaticAbstract
The purpose of this study was to analyze the brain tissue response to several haemostatic agents used during surgery, such as oxidized cellulose polymer and etherified sodium carboxymethyl cellulose on the brain of 30 Oryctolagus cuniculus rabbits. At weeks 1, 2, and 3, the specimens were euthanized. Histological examination showed etherified sodium carboxymethyl cellulose and oxidized cellulose polymer cell response. We established a significant association in foreign body granuloma. It elicited that etherified sodium carboxymethyl cellulose and oxidized cellulose polymer were linked with a substantial foreign body reaction at any point throughout the trial.
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