Intracranial foreign body granuloma caused by oxidized cellulose polymer and etherified sodium carboxymethyl cellulose: an experimental study with orictolagus cuniculus rabbits

https://doi.org/10.31295/ijhms.v4n2.1741

Authors

  • Fitra Department of Neurosurgery, Faculty of Medicine of Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Djoko Legowo Veterinary Faculty, Airlangga University, Surabaya, Indonesia
  • Budi Utomo Faculty of Medicine, Airlangga University, Surabaya, Indonesia
  • Nur Setiawan Suroto Department of Neurosurgery, Faculty of Medicine of Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Muhammad Arifin Parenrengi Department of Neurosurgery, Faculty of Medicine of Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Asra Al-Fauzi Department of Neurosurgery, Faculty of Medicine of Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Keywords:

etherified sodium carboxymethyl cellulose, granuloma, oryctolagus cuniculus rabbits, oxidized cellulose polymer, topical hemostatic

Abstract

The purpose of this study was to analyze the brain tissue response to several haemostatic agents used during surgery, such as oxidized cellulose polymer and etherified sodium carboxymethyl cellulose on the brain of 30 Oryctolagus cuniculus rabbits. At weeks 1, 2, and 3, the specimens were euthanized. Histological examination showed etherified sodium carboxymethyl cellulose and oxidized cellulose polymer cell response. We established a significant association in foreign body granuloma. It elicited that etherified sodium carboxymethyl cellulose and oxidized cellulose polymer were linked with a substantial foreign body reaction at any point throughout the trial.

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Published

2021-08-26

How to Cite

Fitra, Legowo, D., Utomo, B., Suroto, N. S., Parenrengi, M. A., & Al-Fauzi, A. (2021). Intracranial foreign body granuloma caused by oxidized cellulose polymer and etherified sodium carboxymethyl cellulose: an experimental study with orictolagus cuniculus rabbits. International Journal of Health & Medical Sciences, 4(2), 267-272. https://doi.org/10.31295/ijhms.v4n2.1741

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