Tranexamic acid-induced seizures in parturient patient during sectio caesarean

Rania Adeastri Hapsari, Tendi Novara — Tue, 09 Jul 2024 00:00:00 +0000

Introduction: Tranexamic acid has found extensive application in obstetrics to prevent and treat postpartum hemorrhage (PPH). This case report investigated an infrequent incidence in which seizures were caused by the administration of tranexamic acid. Even though tranexamic acid is generally regarded as safe, it has been associated with the infrequent yet serious side effects of tranexamic acid-induced seizures. This case report was aimed at investigating the infrequent incidence of tranexamic acid-induced seizures in postpartum patients. Case: It was reported that a woman who was 40 weeks pregnant suffered from postpartum seizures after delivery via cesarean section. These seizures occurred after tranexamic acid was administered to treat postpartum hemorrhage (PPH) caused by uterine rupture, which was accompanied by hypocalcemia. Despite not having a history of epilepsy, preeclampsia, or hypertension, the electrocardiogram (EKG) showed a prolongation of the QT interval. A comprehensive diagnostic evaluation, which involved a CT scan of the head and a D-dimer examination, was conducted, revealing no abnormalities. Discussion: Tranexamic acid, a synthetic derivative of lysine, acts as a competitive inhibitor of plasminogen activation, thereby inhibiting the breakdown of fibrin clots.

Aspects of immunology and management of post-splenectomy patients

Ni Made Putri Rahayu Srikandi, Ketut Suardamana — Thu, 11 Jul 2024 00:00:00 +0000

The spleen is the largest lymphatic organ in the body and plays an important role in fighting infection. It works to remove micro-organisms and their products circulating within the bloodstream and produce antibodies to enhance the immune response. The spleen is an intraperitoneal organ that performs vital haematological and immunological functions. It maintains both innate and adaptive immunity and protects the body from microbial infections. Splenectomy is associated with an impairment in immunoglobulin production, antibody-mediated clearance, and phagocytosis leading to an increased risk of infection and sepsis. Overwhelming post-splenectomy infection (OPSI) is a syndrome of fulminant sepsis occurring in splenectomized (asplenic) individuals that is associated with high mortality and morbidity. Early identification of the at-risk patient, early blood cultures before antibiotic administration, and sepsis bundles should be utilized in these patients. Prompt management and aggressive treatment can alter the course of disease in the at-risk splenectomized patient. Overwhelming post-splenectomy infection can be prevented through vaccination and patient education.

International journal of health & medical sciences

Tranexamic acid-induced seizures in parturient patient during sectio caesarean

Aspects of immunology and management of post-splenectomy patients