Survival of white blood cells of mice (mus muscullus l) against adaptation dose of gamma co-60 radiation
Keywords:adaptation response, gamma, mus muscullus l , radiotherapy method, survival cell
Several studies on the effects of low dose radiation have shown a shift in the three main paradigms of radiation biology. One of them is a phenomenon known as adaptation response. The phenomenon of adaptation response is a response that occurs when changes in gene expression can be induced by exposure to low doses of radiation around <0.5Gy. Changes in gene expression in certain circumstances serve to protect cells against the effects of subsequent radiation exposure with higher doses (dose challenges). The purpose of this study was to obtain a radiotherapy method that could show a reduction in patient dosage. In this study, the sample of mice (mus muscullus l) was divided into 6 groups, namely 1 control group and 5 treatment groups. Five treatment groups were given an adaptation dose of 0.05Gy for treatment I; 0.10Gy treatment II, 0.15Gy treatment III, 0.2 Gy treatment IV, and treatment V; 0.25Gy. Furthermore, all treatments were immediately given a challenge dose 3Gy. The results of the analysis showed that the lowest leukocyte cell survival occurred on day 30 and returned to normal conditions on day 60 after gamma Co-60 radiation.
Alatas, Z. 2006. Biological Indicators of Damage to the Body Due to Radiation Exposure. Alara Bulletin, 4, August.
Brooks, N., Adger, W. N., & Kelly, P. M. (2005). The determinants of vulnerability and adaptive capacity at the national level and the implications for adaptation. Global environmental change, 15(2), 151-163. https://doi.org/10.1016/j.gloenvcha.2004.12.006
Chan, A. J., Islam, M. K., Rosewall, T., Jaffray, D. A., Easty, A. C., & Cafazzo, J. A. (2010). The use of human factors methods to identify and mitigate safety issues in radiation therapy. Radiotherapy and Oncology, 97(3), 596-600. https://doi.org/10.1016/j.radonc.2010.09.026
Evans, C. M., Mackintosh, J. H., Kennedy, J. F., & Robertson, S. M. (1978). Attempts to characterise and isolate aggression reducing olfactory signals from the urine of female mice Mus musculus L. Physiology & behavior, 20(2), 129-134. https://doi.org/10.1016/0031-9384(78)90064-1
Haley, T. J. (1965). Pharmacology and toxicology of the rare earth elements. Journal of pharmaceutical sciences, 54(5), 663-670. https://doi.org/10.1002/jps.2600540502
Hall, E. J. (2000). Hyperthermia. Radiobiology for the Radiologist. 5th edn. Ed. EJ Hall.
Hall, E. J. (2003). The bystander effect. Health physics, 85(1), 31-35.
Hucklebridge, F. H., Gamal-el-Din, L., & Brain, P. F. (1981). Social status and the adrenal medulla in the house mouse (Mus musculus, L.). Behavioral and Neural Biology, 33(3), 345-363. https://doi.org/10.1016/S0163-1047(81)92110-5
Kadhim, M. A., Moore, S. R., & Goodwin, E. H. (2004). Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 568(1), 21-32. https://doi.org/10.1016/j.mrfmmm.2004.06.043
Lusiyanti, Y., & Syaifudin, M. (2008). The Application of Effects of Interaction Between Radiation and Biological System as Biological Dosimeter; Penerapan Efek Interaksi Radiasi dengan Sistem Biologi sebagai Dosimeter Biologi.
Mayerni, Ahmad, A. and Abidin, Z., 2013. The Impact of Radiation on the Health of Radiation Workers at Arifin Ahmad Hospital, Santa Maria Hospital and Awal Bros Hospital in Pekanbaru. Journal of Environmental Science. Riau Provincial Health Office, Jl. Cut Nyak Dien III Pekanbaru. Vol. 7. No.1.
Moskalev, A. A., Plyusnina, E. N., & Shaposhnikov, M. V. (2011). Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. Biogerontology, 12(3), 253-263.
Okazaki, Y., & Gotoh, E. (2005). Comparison of metal release from various metallic biomaterials in vitro. Biomaterials, 26(1), 11-21. https://doi.org/10.1016/j.biomaterials.2004.02.005
Olivieri, G., Bodycote, J., & Wolff, S. (1984). Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science, 223(4636), 594-597.
Sun, Y., Yu, X. L., Luo, W., Lee, A. W., Wee, J. T. S., Lee, N., ... & Mao, Y. P. (2014). Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy. Radiotherapy and oncology, 110(3), 390-397. https://doi.org/10.1016/j.radonc.2013.10.035
Widyasari, F. N. (2019). Perbandingan Pengaruhmetode Pemberian Nutrisi Enteral Kontinyu Danbolus Terhadap Skor Apache II dan Kadar Prokalsitonin pada Pasien Sepsis di Ruang Perawatan Intensifrsud Dr. Moewardi (Doctoral dissertation, UNS (Sebelas Maret University)).
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