Features of the frequency of distribution of alleles and genotypes of polymorphisms of the gene Tnf-A (G-308a) in patients with rhinosinusitis and the assessment of their role in the development of this pathology

Nargiza Fotikhovna Yarmukhamedova; Dilfuza Saburovna Matkarimova; Shakhlo Khamidullaevna Bakieva; Feruza Ibodullaevna Salomova

doi:10.31295/ijhms.v4n1.1671

Authors

Nargiza Fotikhovna Yarmukhamedova
yanargiza@mail.ru
Assistant, Department of “Otolaryngology and Dentistry”, Tashkent Medical Academy
Dilfuza Saburovna Matkarimova Associate Professor, Department of Hematology, “Transfusiology and Laboratory Science”, Tashkent Medical Academy
Shakhlo Khamidullaevna Bakieva Professor, Department of “Otolaryngology and Dentistry”, Tashkent Medical Academy
Feruza Ibodullaevna Salomova Head of the Department of “Environmental Hygiene”, Tashkent Medical Academy

Keywords:

allele of genes, frequencies of distribution of alleles, genotypes of polymorphisms of gene TNF-α (G-308A), polymorphism of genotypes, rhinosinusitis

Abstract

In this work, we present the results of studying the characteristics of the distribution of allelic and genotypic frequencies of polymorphic variants of the cytokine gene TNF-? (G-308A) among patients with rhinosinusitis with and without chronic myeloid leukemia (CML), as well as among conditionally healthy individuals. At the same time, we assessed the role of this gene in the development of rhinosinusitis. Analysis of the frequency of occurrence of alleles and genotypes for gene TNF-? (G-308A) polymorphism revealed insignificant differences in the 1st main group of CML patients with rhinosinusitis compared with the control group. Thus, the established absence of significant differences in the frequency of occurrence of the A allele (7.7% versus 8.1%; ?2 <3.85; p> 0.05; OR = 0.95; 95% CI: 0.43-2.6) and genotype G/A (15.4% against 16.2%; ?2<3.85; p> 0.05; OR = 0.94; 95% CI: 0.37-2.4), indicates the absence of their significance in the increased risk of rhinosinusitis in the main group of CML patients. A similar picture was also observed in subgroups 1A and 1B of patients in the main group.

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