Effectiveness of Averrhoa bilimbi leaf extract on spermatogenic cells of mice (Mus Musculus L.) hyperglycemia
Keywords:
Averrhoa bilimbi, hyperglycemia, spermatogenic cellsAbstract
The purpose of this study was to determine the effect of giving Averrhoa bilimbi leaf extract on sperm quality of diabetic mice. This research is a pure experimental (true experimental) with a post-test-only control group design approach. This research was conducted by giving Averrhoa bilimbi leaf extract as a treatment for 42 days in male mice. Sperm quality parameters observed included viability, abnormalities, motility in sperm. In all variables, the results of the data showing a normal distribution with a p-value > 0.05 were then carried out with a parametric test using one-way ANOVA. Averrhoa bilimbi leaf extract can increase the number of spermatogenic cells in male mice with hyperglycemia.
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AbdEl-Moniem, M., Mustafa, H. N., Megahed, H. A., Agaibyi, M. H., Hegazy, G. A., & El-Dabaa, M. A. (2015). The ameliorative potential of Hyphaene thebaica on streptozotocin-induced diabetic nephropathy. Folia morphologica, 74(4), 447-457.
Adelati, S., Juniarto, A. Z., & Miranti, I. P. (2016). Histopatologi spermatogenesis testis tikus Wistar diabetes melitus (Doctoral dissertation, Diponegoro University).
Auwal, M., Sanda, K., Mairiga, I., Lawan, F., Mutah, A., Tijjani, A., ... & Thaluvwa, A. (2013). The phytochemical, elemental and hematologic evaluation of crude mesocarp extract of Hyphaene thebaica (doumpalm) in wistar albino rats. Asian J. Biochem, 8(1), 14-23.
Budiani, N., Karmaya, N. M., Manuaba, I. P., & Satriyasa, B. K. (2017). The Number of Leydig Cells, Sertoli Cells, and Spermatogonia are Lower towards a Little Rats that Their Parent Given Genistein during Periconception Period. International Research Journal of Engineering, IT & Scientific Research (IRJEIS), 3(2), 1-8.
Chari, M. G., & Colagar, A. H. (2011). Seminal plasma lipid peroxidation, total antioxidant capacity, and cigarette smoking in asthenoteratospermic men. Journal of Men's Health, 8(1), 43-49.
Corona, G., Giagulli, V. A., Maseroli, E., Vignozzi, L., Aversa, A., Zitzmann, M., ... & Maggi, M. (2016). Testosterone supplementation and body composition: results from a meta-analysis of observational studies. Journal of endocrinological investigation, 39(9), 967-981.
Dalimartha, S. (2004). Ramuan Tradisional untuk Pengobatan Diabetes melitus, Dalam: Buku Ajar Fitokimia.
Fathoni, A., Adiputra, N., Pangkahila, J. A., & Adiatmika, I. P. G. (2018). Reduction of levels postprandial blood glucose on medium intensity physical exercise in intervals and continues. International research journal of engineering, IT & scientific research, 4(6), 10-32.
Garber, S. E., Shabahang, S., Escher, A. P., & Torabinejad, M. (2009). The effect of hyperglycemia on pulpal healing in rats. Journal of endodontics, 35(1), 60-62. https://doi.org/10.1016/j.joen.2008.09.010
Gülçin, I. (2012). Antioxidant activity of food constituents: an overview. Archives of toxicology, 86(3), 345-391.
Hasim, H., Arifin, Y. Y., Andrianto, D., & Faridah, D. N. (2019). Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi) sebagai Antioksidan dan Antiinflamasi. Jurnal Aplikasi Teknologi Pangan, 8(3), 86-93.
Iacobellis, G., Penaherrera, C. A., Bermudez, L. E., & Mizrachi, E. B. (2020). Admission hyperglycemia and radiological findings of SARS-CoV2 in patients with and without diabetes. Diabetes research and clinical practice, 164, 108185. https://doi.org/10.1016/j.diabres.2020.108185
Johnson, M. H., & Everitt, B. J. (1988). Coitus and fertilization. Essential Reproduction. Blackwell.
Kali?anin, B., & Velimirovi?, D. (2012). Potentiometric stripping analysis of zinc, cadmium and lead in tobacco leaves (Nicotiana Tabacum L.) and soil samples. Int J Electrochem Sci, 7, 313-323.
Kasturi, S. S., Tannir, J., & Brannigan, R. E. (2008). The metabolic syndrome and male infertility. Journal of andrology, 29(3), 251-259.
Khourdaji, I., Lee, H., & Smith, R. P. (2018). Frontiers in hormone therapy for male infertility. Translational andrology and urology, 7(Suppl 3), S353.
Kurup, S. B., & Mini, S. (2017). Averrhoa bilimbi fruits attenuate hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats. Journal of food and drug analysis, 25(2), 360-368. https://doi.org/10.1016/j.jfda.2016.06.007
McCowen, K. C., Malhotra, A., & Bistrian, B. R. (2001). Stress-induced hyperglycemia. Critical care clinics, 17(1), 107-124. https://doi.org/10.1016/S0749-0704(05)70154-8
Pala, F. S., & Tabakç?o?lu, K. (2007). Free radicals: Our enemies or friends?.
Parhizkar, S., Yusoff, M. J., & Dollah, M. A. (2013). Effect of Phaleria macrocarpa on sperm characteristics in adult rats. Advanced pharmaceutical bulletin, 3(2), 345.
Pushparaj, P. N., Tan, B. K. H., & Tan, C. H. (2001). The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin-diabetic rats. Life Sciences, 70(5), 535-547. https://doi.org/10.1016/S0024-3205(01)01423-0
Pushparaj, P., Tan, C. H., & Tan, B. K. H. (2000). Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats. Journal of ethnopharmacology, 72(1-2), 69-76. https://doi.org/10.1016/S0378-8741(00)00200-2
Serrano, C. J., Treviño, C. L., Felix, R., & Darszon, A. (1999). Voltage-dependent Ca2+ channel subunit expression and immunolocalization in mouse spermatogenic cells and sperm. FEBS letters, 462(1-2), 171-176. https://doi.org/10.1016/S0014-5793(99)01518-5
Sisein, E. A. (2014). Biochemistry of free radicals and antioxidants. Scholars Academic Journal of Biosciences, 2(2), 110-118.
Tan, B. K. H., Tan, C. H., & Pushparaj, P. N. (2005). Anti–diabetic activity of the semi–purified fractions of Averrhoa bilimbi in high fat diet fed–streptozotocin–induced diabetic rats. Life sciences, 76(24), 2827-2839. https://doi.org/10.1016/j.lfs.2004.10.051
Treviño, C. L., Serrano, C. J., Beltrán, C., Felix, R., & Darszon, A. (2001). Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm. FEBS letters, 509(1), 119-125. https://doi.org/10.1016/S0014-5793(01)03134-9
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84.
Vicari, E., & Calogero, A. E. (2001). Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Human Reproduction, 16(11), 2338-2342.
Yanagimachi, R. (2005). Intracytoplasmic injection of spermatozoa and spermatogenic cells: its biology and applications in humans and animals. Reproductive biomedicine online, 10(2), 247-288. https://doi.org/10.1016/S1472-6483(10)60947-9
Zuhra, C. F., Tarigan, J. B., & Sihotang, H. (2008). Aktivitas antioksidan senyawa flavonoid dari daun katuk (Sauropus androgunus (L) Merr.). Jurnal Biologi Sumatera, 3(1), 7-10.
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