Survival of white blood cells of mice (Mus musculus L) on interval AD with CD post gamma radiation Co-60

Gusti Ngurah Sutapa; Ni Nyoman Ratini; Ni Kadek Nova Anggarani; I Gde Antha Kasmawan

doi:10.21744/ijhms.v4n4.1786

Authors

Gusti Ngurah Sutapa
sutapafis97@unud.ac.id
Udayana University, Denpasar, Indonesia
Ni Nyoman Ratini Udayana University, Denpasar, Indonesia
Ni Kadek Nova Anggarani Udayana University, Denpasar, Indonesia
I Gde Antha Kasmawan Udayana University, Denpasar, Indonesia

Keywords:

adaptation dose, cell survival, challenge dose, radiotherapy method, white blood

Abstract

One of the phenomena of the low-dose radiation effect is the radio adaptation response which is an important part of the response of molecules, cells, and body tissues to ionizing radiation. The phenomenon of radio adaptation response is a response that occurs when changes in gene expression can be induced by exposure to low doses of radiation (<0.5 Gy). Changes in the expression of this gene under certain circumstances serve to protect cells against the effects caused by subsequent exposure to higher doses of radiation, so this situation is known as an adaptive response or radio adaptation response. Cells can respond to very low doses of radiation with some changes in gene expression. Beginning with the administration of radiation to cells with a very low dose, known as the adaptation dose (AD), and then in a short period being given a larger dose of radiation, known as the challenge dose (CD), there was a decrease in the number of induced chromosome aberrations when compared to cells that were not irradiated at an adapted dose. The purpose of this study was to obtain a radiotherapy method that could show a reduction in the patient's dose.

Downloads

Download data is not yet available.

References

Alatas, Z. 2006. Biological Indicators of Damage to the Body Due to Radiation Exposure. Alara Bulletin, 4, August.

Ambrogini, P., Cuppini, R., Cuppini, C., Ciaroni, S., Cecchini, T., Ferri, P., ... & Del Grande, P. (2000). Spatial learning affects immature granule cell survival in adult rat dentate gyrus. Neuroscience letters, 286(1), 21-24. https://doi.org/10.1016/S0304-3940(00)01074-0

Castillejos, L., Calsamiglia, S., Ferret, A., & Losa, R. (2007). Effects of dose and adaptation time of a specific blend of essential oil compounds on rumen fermentation. Animal Feed Science and Technology, 132(3-4), 186-201. https://doi.org/10.1016/j.anifeedsci.2006.03.023

Confer, A. W., Hall, S. M., Faulkner, C. B., Espe, B. H., Deyoe, B. L., Morton, R. J., & Smith, R. A. (1985). Effects of challenge dose on the clinical and immune responses of cattle vaccinated with reduced doses of Brucella abortus strain 19. Veterinary microbiology, 10(6), 561-575. https://doi.org/10.1016/0378-1135(85)90065-3

Desprez, P. Y. (2011). Radio-Adaptive Response and Breast Cancer. California Pacific Medical Center Research Inst San Francisco.

Djan, I., Solajic, S., Djan, M., Vucinic, N., Popovic, D., Ilic, M., ... & Bogdanovic, G. (2014). Radiobiological effects of multiple vs. single low-dose pre-irradiation on the HT29 cell line. Contemporary Oncology, 18(4), 230.

Donovan, E., Bleakley, N., Denholm, E., Evans, P., Gothard, L., Hanson, J., ... & Yarnold, J. (2007). Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiotherapy and Oncology, 82(3), 254-264. https://doi.org/10.1016/j.radonc.2006.12.008

Hall, E. J., & Giaccia, A. J. (2006). Radiobiology for the Radiologist (Vol. 6).

Harahap, N. S. (2008). Pengaruh aktifitas fisik maksimal terhadap jumlah leukosit dan hitung jenis leukosit pada mencit (Mus Musculus L) jantan. USU e-ropository. Medan.

Hindséna, M., Bruzea, M., & Christensenb, O. B. (2001). Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions. Journal of the American Academy of Dermatology, 44(4), 616-623. https://doi.org/10.1067/mjd.2001.110873

Jacks, T., & Weinberg, R. A. (2002). Taking the study of cancer cell survival to a new dimension. Cell, 111(7), 923-925. https://doi.org/10.1016/S0092-8674(02)01229-1

Jacob, T. J., Fraser, C., Wang, L., Walker, V., & O'Connor, S. (2003). Psychophysical evaluation of responses to pleasant and mal-odour stimulation in human subjects; adaptation, dose response and gender differences. International Journal of Psychophysiology, 48(1), 67-80. https://doi.org/10.1016/S0167-8760(03)00020-5

Kadhim, M. A., Moore, S. R., & Goodwin, E. H. (2004). Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 568(1), 21-32.

Kusumayanti, G. D., & Dewantari, N. M. (2017). The influence of low purine diet and physical activity on changing of uric acid levels in hyperuricemia. International Journal of Health Sciences, 1(3), 1-9. https://doi.org/10.21744/ijhs.v1i3.45

Lusiyanti, Y., & Syaifudin, M. (2008, May). The Application of Effects of Interaction Between Radiation and Biological System as Biological Dosimeter; Penerapan Efek Interaksi Radiasi dengan Sistem Biologi sebagai Dosimeter Biologi. In Jurnal Forum Nuklir (Vol. 2).

Mayerni, M., Ahmad, A., & Abidin, Z. (2009). Dampak Radiasi Terhadap Kesehatan Pekerja Radiasi Di Rsud Arifin Achmad, Rs Santa Maria Dan Rs Awal Bros Pekanbaru. Jurnal Ilmu Lingkungan, 7(1), 114-127.

Okazaki, R., Ootsuyama, A., & Norimura, T. (2005). Radioadaptive response for protection against radiation-induced teratogenesis. Radiation research, 163(3), 266-270.

Pearce, P. L. (2005). Tourist behaviour: Themes and conceptual schemes. Channel View Publications.

Romero, R., Yoon, B. H., Mazor, M., Gomez, R., Diamond, M. P., Kenney, J. S., ... & Sehgal, P. (1993). The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes. American journal of obstetrics and gynecology, 169(4), 805-816. https://doi.org/10.1016/0002-9378(93)90009-8

Schattner, A. D. G. T. S. M., Merlin, G., Levin, S., Wallach, D., Hahn, T., & Revel, M. (1981). Assay of an interferon-induced enzyme in white blood cells as a diagnostic aid in viral diseases. The Lancet, 318(8245), 497-500. https://doi.org/10.1016/S0140-6736(81)90883-7

Schwartz, D. L., Garden, A. S., Shah, S. J., Chronowski, G., Sejpal, S., Rosenthal, D. I., ... & Dong, L. (2013). Adaptive radiotherapy for head and neck cancer—dosimetric results from a prospective clinical trial. Radiotherapy and Oncology, 106(1), 80-84. https://doi.org/10.1016/j.radonc.2012.10.010

Sisworo, G. S. (2007). Korelasi Antara Tingkat Stres Kerja Dan Hipertensi (Doctoral dissertation, Universitas Airlangga).

Sloane, N. J. (2003). The on-line encyclopedia of integer sequences.

Sulaeman, R., Muhasidah, .-., Purnamawati, D., Zulkifli, .-., Jafar, S. R., & Suiraoka, I. P. (2018). Progressive muscle relaxation using video aids reduces blood pressure of hypertension patients. International Journal of Health Sciences, 2(3), 33-42. https://doi.org/10.29332/ijhs.v2n3.214

Sutapa, G. N., Astra, I. M. K. A., & Soejoko, D. S. (2014). In vivo Radioadaptive Response of White Blood Cells (Leukocytes) Quantity in Mouse (Mus musculus L) Blood to Co-60 Gamma Radiation Exposures. And Risks Of Ionizing Radiation (SERIR) BALI, 10-11 OCTOBER 2013, 1, 293.