The change of BDNF expression in traumatic brain injury after Kaempferia galanga L. administration: An experimental study

Achmad Kurniawan; Agus Turchan; Budi Utomo; Muhammad Arifin Parenrengi; Dyah Fauziah

doi:10.21744/ijhms.v5n1.1847

Authors

Achmad Kurniawan Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Agus Turchan
agusturchan@yahoo.com
Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Budi Utomo Department of Public Health Science and Preventive Medicine, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Muhammad Arifin Parenrengi Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Dyah Fauziah Department of Pathology Anatomi, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia

Keywords:

BDNF, experimental study, Kaempferia galanga L., traumatic brain injury, wistar rats

Abstract

BDNF has potent effects on neural synapses and its pathway affects cell survival and other biological processes. Kaempferia galanga L. has many active substances with antioxidant and anti-inflammatory effects. We analyzes BDNF in four different group of Wistar rats (Ratus novergicus) into Groups A (no trauma & extract), B (with trauma & no extract), C (with trauma and 600 mg/kgbw extract), and D (with trauma and 1200 mg/kgbw extract). Groups B, C, and D are further divided into those who had their BDNF measured on 24- (B₂₄, C₂₄, and D₂₄) and 48-hours. BDNF expression were found to be statistically significant between Group A with both B₂₄ (p = 0,009) and D₂₄ (p = 0,009) on the 24-hour post-trauma decapitation analysis. On the 48 hours after trauma and extract administration, Group B₄₈(p = 0,002), C₄₈(p = <0,001), and D₄₈(p <0,001) were found to be significantly different with Group A. The administration of Kaempferia galanga L. extract can be considered as an option in increasing brain BDNF levels which are neuroprotective. Larger and specific studies are needed to determine the appropriate dose and duration.

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