Expression malondialdehyde (MDA) of brain after injury with the extract of kencur (Kaempferia Galanga L): Experimental study wistar rats

Mahendra Budi Sagita; Agus Turchan; Budi Utomo; Asra Al Fauzi; Dyah Fauziah

doi:10.21744/ijhms.v5n1.1848

Authors

Mahendra Budi Sagita Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Agus Turchan
agusturchan@yahoo.com
Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Budi Utomo Department of Public Health Science and Preventive Medicine, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Asra Al Fauzi Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Dyah Fauziah Department of Pathology Anatomi, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia

Keywords:

expression malondialdehyde (MDA), brain after injury, extract of kencur, experimental study Wistar rats, Kaempferia Galanga L

Abstract

Neurological damage in brain injury occurs due to secondary brain injury. Kencur extract has antioxidant potential with total phenolic and flavonoid content including luteolin apigenin and is expected to reduce MDA expression to prevent secondary injury. This study is an experimental laboratory. The treatment of all samples was carried out simultaneously using a post-test-only control group design. Based on the ANOVA test, the significance value of the Kencur extract treatment group was 0.000 (p<0.05) indicating that there was a difference in MDA expression in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. In the 24-hour and 48-hour time groups, a significance value of 0.488 (p> 0.05) showed no significant difference in MDA expression. Then the Kencur extract treatment group with a time group of 0.117 (p> 0.05) showed no significant difference in MDA expression. There was a significant difference in the expression of MDA in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. There were no significant differences in the MDA expression in the 24-hour and 48-hour time groups and the Kencur extract treatment group and the 24-hour and 48-hour time groups.

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