Association between hemoglobin levels and depression status in geriatric patients at Prof. DR. I. G. N. G. Ngoerah General Hospital

Ni Wayan Kertiasih; Made Nopriantha; Anak Ayu Sri Wahyuni; Ni Ketut Sri Diniari; R A Tuty Kuswardhani

doi:10.21744/ijhms.v6n2.2105

Authors

Ni Wayan Kertiasih
asih_4sma@yahoo.com
Udayana University, Denpasar, Indonesia
Made Nopriantha Udayana University, Denpasar, Indonesia
Anak Ayu Sri Wahyuni Udayana University, Denpasar, Indonesia | Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, Indonesia
Ni Ketut Sri Diniari Udayana University, Denpasar, Indonesia | Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, Indonesia
RA Tuty Kuswardhani Udayana University, Denpasar, Indonesia | Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, Indonesia

Keywords:

anemia, depression, elderly, hemoglobin

Abstract

Background: There is evidence of decreased hemoglobin levels as long as an ageing process in the elderly. Low hemoglobin level conditions not only influence physical status but also mental function in the elderly. Objective: to know the association between hemoglobin level and depression status in the elderly. Methods: This is an analytic cross-sectional study. Data were derived from medical records of elderly/Geriatric patients (age>60 years old) admitted to the Internal Medicine Department of Prof. Dr. I.G.N.G. Ngoerah General Hospital between January to July 2018. Anemia status was defined using WHO criteria and depression was defined using Geriatric Depression Scale (GDS) questionnaires. We use an independent t-test to know the association between a categorical and numeric variable with normal distribution. Statistically significant if p < 0.05. Results: A total of 102 patient was enrolled in this study consisting of 47,05% male and 52,94% female. The prevalence of depression in the elderly was 27,45% and there is no statistically different based on age and sex. There is an association between hemoglobin level and depression in the elderly (p=0,037; CI 0,76-3,14). Logistic regression analysis shows that age and hemoglobin level impact depression status in the elderly.

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References

Alexopoulos, G. S. (2005). Depression in the elderly. The lancet, 365(9475), 1961-1970. https://doi.org/10.1016/S0140-6736(05)66665-2

Barua, A., Ghosh, M. K., Kar, N., & Basilio, M. A. (2011). Prevalence of depressive disorders in the elderly. Annals of Saudi medicine, 31(6), 620-624.

Beghé, C., Wilson, A., & Ershler, W. B. (2004). Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. The American journal of medicine, 116(7), 3-10. https://doi.org/10.1016/j.amjmed.2003.12.009

Blazer, D. G. (2003). Depression in late life: review and commentary. The journals of gerontology series A: Biological sciences and medical sciences, 58(3), M249-M265.

Carman, W. F., Elder, A. G., Wallace, L. A., McAulay, K., Walker, A., Murray, G. D., & Stott, D. J. (2000). Effects of influenza vaccination of health-care workers on mortality of elderly people in long-term care: a randomised controlled trial. The Lancet, 355(9198), 93-97. https://doi.org/10.1016/S0140-6736(99)05190-9

Cesari, M., Penninx, B. W., Lauretani, F., Russo, C. R., Carter, C., Bandinelli, S., ... & Ferrucci, L. (2004). Hemoglobin levels and skeletal muscle: results from the InCHIANTI study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59(3), M249-M254.

Chen, H. H., Yeh, H. L., & Tsai, S. J. (2012). Association of lower hemoglobin levels with depression, though not with cognitive performance, in healthy elderly men. Psychiatry and clinical neurosciences, 66(4), 367-369.

Corona, L. P., Duarte, Y. A. D. O., & Lebrão, M. L. (2014). Prevalence of anemia and associated factors in older adults: evidence from the SABE Study. Revista de Saúde Pública, 48, 723-431.

Ernawati, E., Baso, Y. S., Hidayanty, H., Syarif, S., Aminuddin, A., & Bahar, B. (2022). The effects of anemia education using web-based she smart to improve knowledge, attitudes, and practice in adolescent girls. International Journal of Health & Medical Sciences, 5(1), 44-49. https://doi.org/10.21744/ijhms.v5n1.1831

Fishbane, S., & Berns, J. S. (2005). Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin. Kidney international, 68(3), 1337-1343. https://doi.org/10.1111/j.1523-1755.2005.00532.x

Foley, R. N., Parfrey, P. S., Morgan, J., Barré, P. E., Campbell, P., Cartier, P., ... & Wells, G. A. (2000). Effect of hemoglobin levels in hemodialysis patients with asymptomatic cardiomyopathy. Kidney international, 58(3), 1325-1335. https://doi.org/10.1046/j.1523-1755.2000.00289.x

Gangat, N., & Wolanskyj, A. P. (2013). Anemia of chronic disease. In Seminars in hematology (Vol. 50, No. 3, pp. 232-238). WB Saunders. https://doi.org/10.1053/j.seminhematol.2013.06.006

Gaskell, H., Derry, S., Andrew Moore, R., & McQuay, H. J. (2008). Prevalence of anaemia in older persons: systematic review. BMC geriatrics, 8(1), 1-8.

Hamer, M., & Molloy, G. J. (2009). Cross?sectional and longitudinal associations between anemia and depressive symptoms in the English Longitudinal Study of Ageing. Journal of the American Geriatrics Society, 57(5), 948-949.

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., ... & Wang, P. S. (2003). The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). Jama, 289(23), 3095-3105.

Kuo, P. L., & Pu, C. (2011). The contribution of depression to mortality among elderly with self-reported hypertension: analysis using a national representative longitudinal survey. Journal of hypertension, 29(11), 2084-2090.

Levinson, D. F. (2006). The genetics of depression: a review. Biological psychiatry, 60(2), 84-92. https://doi.org/10.1016/j.biopsych.2005.08.024

McKay, K. M., Imel, Z. E., & Wampold, B. E. (2006). Psychiatrist effects in the psychopharmacological treatment of depression. Journal of affective disorders, 92(2-3), 287-290. https://doi.org/10.1016/j.jad.2006.01.020

Mirkena, Y., Reta, M. M., Haile, K., Nassir, Z., & Sisay, M. M. (2018). Prevalence of depression and associated factors among older adults at ambo town, Oromia region, Ethiopia. BMC psychiatry, 18, 1-7.

MS D. (2015). Statistik untuk Kedokteran dan Kesehatan. 15 ed. Jakarta: Epidemiologi Indonesia.

Onder, G., Penninx, B. W., Cesari, M., Bandinelli, S., Lauretani, F., Bartali, B., ... & Ferrucci, L. (2005). Anemia is associated with depression in older adults: results from the InCHIANTI study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60(9), 1168-1172.

Onder, G., Penninx, B. W., Landi, F., Atkinson, H., Cesari, M., Bernabei, R., & Pahor, M. (2003). Depression and adverse drug reactions among hospitalized older adults. Archives of internal medicine, 163(3), 301-305.

Penninx, B. W., Geerlings, S. W., Deeg, D. J., van Eijk, J. T., van Tilburg, W., & Beekman, A. T. (1999). Minor and major depression and the risk of death in older persons. Archives of general psychiatry, 56(10), 889-895.

Quan, H., Li, B., Couris, C. M., Fushimi, K., Graham, P., Hider, P., ... & Sundararajan, V. (2011). Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. American journal of epidemiology, 173(6), 676-682.

Richard, P. (2016). Blood loss anemia. Making a distinction between acute and chronic blood loss anemia is important. ACP Hospitalist and American College of Physicians: ACP Hospitalist and American College of Physicians.

Ruo, B., Rumsfeld, J. S., Hlatky, M. A., Liu, H., Browner, W. S., & Whooley, M. A. (2003). Depressive symptoms and health-related quality of life: the Heart and Soul Study. Jama, 290(2), 215-221.

Shafi, M., Taufiq, F., Mehmood, H., Afsar, S., & Badar, A. (2018). Relation between depressive disorder and iron deficiency anemia among adults reporting to a secondary healthcare facility: a hospital-based case control study. J Coll Physicians Surg Pak, 28(6), 456-559.

Stauder, R., & Thein, S. L. (2014). Anemia in the elderly: clinical implications and new therapeutic concepts. Haematologica, 99(7), 1127.

Steensma, D. P., & Tefferi, A. (2007). Anemia in the elderly: how should we define it, when does it matter, and what can be done?. In Mayo Clinic Proceedings (Vol. 82, No. 8, pp. 958-966). Elsevier. https://doi.org/10.4065/82.8.958

Tefferi, A. (2003). Anemia in adults: a contemporary approach to diagnosis. In Mayo Clinic Proceedings (Vol. 78, No. 10, pp. 1274-1280). Elsevier. https://doi.org/10.4065/78.10.1274

Umegaki, H., Yanagawa, M., & Endo, H. (2011). Association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care. Geriatrics & gerontology international, 11(3), 262-266.

Vulser, H., Wiernik, E., Hoertel, N., Thomas, F., Pannier, B., Czernichow, S., ... & Lemogne, C. (2016). Association between depression and anemia in otherwise healthy adults. Acta Psychiatrica Scandinavica, 134(2), 150-160.