Bone tumor wide excision due to giant cell tumor of proximal humerus
A case report
Keywords:
bone tumor, giant cell tumor, patient, proximal humerus, wide excisionAbstract
Introduction: Giant Cell Tumors are benign, aggressive tumors typically found in the epiphysis of long bones. It has a potential for aggressive behaviour and the capacity to metastasize. the most common symptom of a giant cell tumor is a pain in the area of the tumor. The patient may also have pain with the movement of the nearby joint. Case: We reported an 18-year-old boy with an extensive giant-cell tumor of proximal humerus. Radiograph show a primary malignant bone tumour proximal humerus dextra with soft tissue swelling. There was a lytic lesion, with wide zone transition on proximal humerus dextra, and a trabeculated bone outside the normal lesion was treated by segmental resection and shoulder reconstruction. A prosthesis was used to reconstruct the shoulder joint, the rotator cuff was reattached to the bone after making a semicircular trough. Discussion: There are several therapy options for the patient, the non-operative and operative therapy. The non-operative way such as radiation therapy, medication therapy, and tumor embolization. The operative way such as extensive, complete resection, and amputation. Conclusion: Wide excision is suitable for this patient, we can save normal tissue and do some shoulder reconstruction.
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Adulkasem, N., & Pruksakorn, D. (2019). Giant cell tumour of the middle phalanx of the middle finger. BMJ Case Reports CP, 12(3), e229076.
Azar, F. M., Canale, S. T., & Beaty, J. H. (2020). Campbell's Operative Orthopaedics, E-Book. Elsevier Health Sciences.
Buchanan, D. J., Schlaerth, J., & Kurosaki, T. (1998). Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. American journal of obstetrics and gynecology, 178(6), 1177-1184. https://doi.org/10.1016/S0002-9378(98)70320-5
Burke, T. W., Levenback, C., Coleman, R. L., Morris, M., Silva, E. G., & Gershenson, D. M. (1995). Surgical therapy of T1 and T2 vulvar carcinoma: further experience with radical wide excision and selective inguinal lymphadenectomy. Gynecologic oncology, 57(2), 215-220. https://doi.org/10.1006/gyno.1995.1128
Drumond, J. M. N. (2009). Benign bone tumors and tumor-like bone lesions: treatment update and new trends. Revista Brasileira de Ortopedia (English Edition), 44(5), 386-390.
Eriksson, B., Renstrup, J., Imam, H., & Öberg, K. (1997). High-dose treatment with lanreotide of patients with advanced neuroendocrine gastrointestinal tumors: clinical and biological effects. Annals of Oncology, 8(10), 1041-1044. https://doi.org/10.1023/A:1008205415035
Gao, X., Li, L., Cai, X., Huang, Q., Xiao, J., & Cheng, Y. (2021). Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges. Biomaterials, 265, 120404. https://doi.org/10.1016/j.biomaterials.2020.120404
Gruenwald, N., Demos, T. C., Lomasney, L. M., & Rapp, T. (2006). Giant-cell tumor. Orthopedics, 29(2), 94-167.
Jaiswal, A., & Ambade, R. (2023). Tenosynovial giant cell tumour of the finger: a case report. The Pan African Medical Journal, 45.
Journal of Orthopaedic Case Reports | pISSN 2250-0685 | eISSN 2321-3817 | Available on www.jocr.co.in | doi:10.13107/jocr.2019.v09.i06.1566
Kim, Y., Nizami, S., Goto, H., & Lee, F. Y. (2012). Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clinics in Orthopedic Surgery, 4(2), 107-116.
Krappinger, D., Bizzotto, N., Riedmann, S., Kammerlander, C., Hengg, C., & Kralinger, F. S. (2011). Predicting failure after surgical fixation of proximal humerus fractures. Injury, 42(11), 1283-1288. https://doi.org/10.1016/j.injury.2011.01.017
Lau, Y. S., Sabokbar, A., Gibbons, C. L. M. H., Giele, H., & Athanasou, N. (2005). Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. Human pathology, 36(9), 945-954. https://doi.org/10.1016/j.humpath.2005.07.005
Liao, J., Shi, K., Jia, Y., Wu, Y., & Qian, Z. (2021). Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion. Bioactive materials, 6(8), 2221-2230. https://doi.org/10.1016/j.bioactmat.2021.01.006
Matev, B., Georgiev, H., & Georgiev, G. P. (2012). Giant Cell Tumor of the Fourth Metacarpal: Case Report and. Journal of Radiotheraphy & Medical Oncology, 17(2), 73-77.
Mazzaferro, V., Pulvirenti, A., & Coppa, J. (2007). Neuroendocrine tumors metastatic to the liver: how to select patients for liver transplantation?. Journal of hepatology, 47(4), 460-466. https://doi.org/10.1016/j.jhep.2007.07.004
McEnery, K. W., & Raymond, A. K. (1999). Giant cell tumor of the fourth metacarpal. AJR. American journal of roentgenology, 172(4), 1092.
Morii, R., Tsukamoto, S., Righi, A., Honoki, K., Tanaka, Y., Kido, A., ... & Errani, C. (2021). Effect of adjuvant chemotherapy on localized malignant giant cell tumor of bone: a systematic review. Cancers, 13(21), 5410.
Murphey, M. D., Nomikos, G. C., Flemming, D. J., Gannon, F. H., Temple, H. T., & Kransdorf, M. J. (2001). Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics, 21(5), 1283-1309.
NCCN. Bone Cancer NCCN Guidelines (Version 1.2015).
Patel, M. R., Desai, S. S., Gordon, S. L., Nimberg, G. A., Sclafani, S. J., Vigorita, V. J., ... & Sung, H. W. (1987). Management of skeletal giant cell tumors of the phalanges of the hand. The Journal of hand surgery, 12(1), 70-77.
Reilly, K. E., Stern, P. J., & Dale, J. A. (1999). Recurrent giant cell tumors of the tendon sheath. The Journal of hand surgery, 24(6), 1298-1302. https://doi.org/10.1053/jhsu.1999.1298
Roux, A., Decroocq, L., El Batti, S., Bonnevialle, N., Moineau, G., Trojani, C., ... & De Peretti, F. (2012). Epidemiology of proximal humerus fractures managed in a trauma center. Orthopaedics & Traumatology: Surgery & Research, 98(6), 715-719. https://doi.org/10.1016/j.otsr.2012.05.013
Unni, K. K., Inwards, C. Y., Bridge, J. A., Kindblom, L. G., & Wold, L. E. (2005). AFIP atlas of tumor pathology: tumors of the bones and joints. Washington DC: American Registry of Pathology, in collaboration with the Armed Forces Institute of Pathology.
Werner, M. (2006). Giant cell tumour of bone: morphological, biological and histogenetical aspects. International orthopaedics, 30, 484-489.
Yadav, S., Singhal, S., Patel, S., Jaiswal, S., Mishra, R., & Mishra Jr, R. (2022). A Rare Case of Giant-Cell Tumor of Hand in a Young Male. Cureus, 14(1).
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