The relationship between anemia and pneumonia severity in children aged 29 days to 5 years

https://doi.org/10.21744/ijhms.v7n2.2276

Authors

  • Stevan Pagar Pardamean Simanjuntak Waikabubak General Hospital, Indonesia
  • Japendi Rizal Pavliando Saragih Waikabubak General Hospital, Indonesia

Keywords:

anemia, children, hypoxia, immune function, pneumonia severity

Abstract

Background: Pneumonia is an acute infection of the lung parenchyma and is a leading cause of death among children under five worldwide. The World Health Organization (WHO) notes that 15% of all under-five deaths are due to pneumonia, with a prevalence of 3.55% in Indonesia. Anemia, especially iron deficiency anemia, is also a common health issue among children and is associated with increased morbidity and mortality. Anemia is believed to increase the risk and worsen the severity of pneumonia due to hypoxia and impaired immune function. Methods: This cross-sectional study was conducted at Waikabubak General Hospital, West Sumba, on children aged 29 days to 5 years who were hospitalized with pneumonia from January 2022 to December 2023. Pneumonia was defined based on WHO criteria. Anemia was defined as blood hemoglobin levels <11 mg/dL. Exclusion criteria included other conditions that might affect the study results. Data analysis was performed using the Chi-square test to assess the relationship between anemia and pneumonia severity. Results: Of the 399 subjects meeting the criteria, 57.9% were male and 42.1% female. A total of 61.9% were diagnosed with mild to moderate pneumonia, and 38.1% were diagnosed with severe pneumonia. Most subjects (55.8%) had anemia. 

Downloads

Download data is not yet available.

References

Accinelli, R. A., & Leon-Abarca, J. A. (2017). Solid fuel use is associated with anemia in children. Environmental research, 158, 431-435. https://doi.org/10.1016/j.envres.2017.06.032

Aksu, T., & Ünal, ?. (2023). Iron deficiency anemia in infancy, childhood, and adolescence. Turkish Archives of Pediatrics, 58(4), 358.

Behairy, O. G., Mohammad, O. I., & Elshaer, O. S. (2018). Iron-deficiency anemia as a risk factor for acute lower respiratory tract infections in children younger than 5 years. Egyptian Journal of Bronchology, 12, 352-357.

Brabin, B. J., Premji, Z., & Verhoeff, F. (2001). An analysis of anemia and child mortality. The Journal of nutrition, 131(2), 636S-648S. https://doi.org/10.1093/jn/131.2.636S

Cao, L., Ji, Z., Zhang, P., & Wang, J. (2023). Epidemiology and mortality predictors for severe childhood community-acquired pneumonia in ICUs: A retrospective observational study. Frontiers in Pediatrics, 11, 1031423.

Chaudhry, H. S., & Kasarla, M. R. (2017). Microcytic hypochromic anemia.

Chisti, M. J., Kawser, C. A., Rahman, A. S. M. M. H., Shahid, A. S. M. S. B., Afroze, F., Shahunja, K. M., ... & Ahmed, T. (2022). Prevalence and outcome of anemia among children hospitalized for pneumonia and their risk of mortality in a developing country. Scientific Reports, 12(1), 10741.

Gallagher, P. G. (2022). Anemia in the pediatric patient. Blood, The Journal of the American Society of Hematology, 140(6), 571-593.

Gobinaath, J. A. D. (2020). Association between anemia and acute lower respiratory tract infection in under-five children at Puducherry, India: a case control study. Int J Contemp Pediatr, 7(3): 679.

Islam, M. A., Afroja, S., Khan, M. S., Alauddin, S., Nahar, M., & Talukder, A. (2022). Prevalence and triggering factors of childhood anemia: An application of ordinal logistic regression model. International Journal of Clinical Practice, 2022.

Ito, A., Ishida, T., Tokumasu, H., Yamazaki, A., & Washio, Y. (2020). Evaluation of pneumonia severity scoring systems in nursing and healthcare-associated pneumonia for predicting prognosis: a prospective, cohort study. Journal of infection and chemotherapy, 26(4), 372-378. https://doi.org/10.1016/j.jiac.2019.11.001

Jayamanna, U., & Jayaweera, J. S. (2023). Childhood Anemia and Risk for Acute Respiratory Infection, Gastroenteritis, and Urinary Tract Infection: A Systematic Review. Journal of Pediatric Infectious Diseases, 18(02), 061-070.

Juffrie, M., Helmyati, S., & Hakimi, M. (2020). Nutritional anemia in Indonesia children and adolescents: Diagnostic reliability for appropriate management. Asia Pacific Journal of Clinical Nutrition, 29.

Kementrian Kesehatan Republik Indonesia. (2019). Profil kesehatan Indonesa 2019 [Internet]. Kementrian Kesehatan Republik Indonesia. p. 487

Michiels, C. (2004). Physiological and pathological responses to hypoxia. The American journal of pathology, 164(6), 1875-1882. https://doi.org/10.1016/S0002-9440(10)63747-9

Msinde, P. S. (2023). The Prevalence, Etiology, And Outcome Of Anemia In Children Under Five On Admission In Three Hospitals Of Dar-Es-Salaam. medRxiv, 2023-12.

Morey, J. N., Boggero, I. A., Scott, A. B., & Segerstrom, S. C. (2015). Current directions in stress and human immune function. Current opinion in psychology, 5, 13-17. https://doi.org/10.1016/j.copsyc.2015.03.007

Oktafia, P., Airlangga, P. S., Dharmawati, I., & Setyoningrum, R. A. (2021). Risk factors of complicated pneumonia in children. Journal Of The Indonesian Medical Association, 71(3), 135-140.

Reade, M. C., Weissfeld, L., Angus, D. C., Kellum, J. A., & Milbrandt, E. B. (2010). The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia. BMC pulmonary medicine, 10, 1-10.

Saputra, N. W., Kusumawardani, T., & Muryawan, M. H. (2022). Hubungan Anemia Defisiensi Besi dengan Pneumonia pada Anak Usia 6 Bulan–5 Tahun. Medica Hospitalia: Journal of Clinical Medicine, 9(1), 75-80.

Satici, C., Demirkol, M. A., Altunok, E. S., Gursoy, B., Alkan, M., Kamat, S., ... & Esatoglu, S. N. (2020). Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19. International Journal of Infectious Diseases, 98, 84-89. https://doi.org/10.1016/j.ijid.2020.06.038

Shah, F., Kazi, T. G., Afridi, H. I., Baig, J. A., Khan, S., Kolachi, N. F., ... & Shah, A. Q. (2010). Environmental exposure of lead and iron deficit anemia in children age ranged 1–5 years: a cross sectional study. Science of the total environment, 408(22), 5325-5330. https://doi.org/10.1016/j.scitotenv.2010.07.091

Solaini, G., Baracca, A., Lenaz, G., & Sgarbi, G. (2010). Hypoxia and mitochondrial oxidative metabolism. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1797(6-7), 1171-1177. https://doi.org/10.1016/j.bbabio.2010.02.011

Suci, L. N. (2020). Pendekatan Diagnosis dan Tata Laksana Pneumonia pada Anak. Jurnal Kedokteran Nanggroe Medika, 3(1), 30-38.

World Health Organization. (2022). Pneumonia in Children [Internet].

Wahyudi, E., Handayani, T., & Setyoningrum, R. A. (2020). Risk factors of hypoxemia in children with pneumonia. Indian Journal of public health research and development, 11(6), 1226-1230.

Wahyuni, I. S., & Widyaningsih, E. B. (2021). Intervention with Fe supplementations and IEC about anemia against hemoglobin levels in female teenagers in state senior high school. International Journal of Health & Medical Sciences, 4(1), 38-43. https://doi.org/10.31295/ijhms.v4n1.500

Yung, R. L. (2000). Changes in immune function with age. Rheumatic disease clinics of North America, 26(3), 455-473. https://doi.org/10.1016/S0889-857X(05)70151-4

Zhou, J., Schmid, T., Schnitzer, S., & Brüne, B. (2006). Tumor hypoxia and cancer progression. Cancer letters, 237(1), 10-21. https://doi.org/10.1016/j.canlet.2005.05.028

Published

2024-05-22

How to Cite

Simanjuntak, S. P. P., & Saragih, J. R. P. (2024). The relationship between anemia and pneumonia severity in children aged 29 days to 5 years. International Journal of Health & Medical Sciences, 7(2), 30-34. https://doi.org/10.21744/ijhms.v7n2.2276