Association between microcytic-hypochromic anemia and simple febrile seizure in children
Keywords:
anemia, children, febrile seizure, microcytic-hypochromic anemiaAbstract
Aims: This research aims to assess the impact of microcytic-hypochromic anemia on first febrile seizures in children, given its high incidence in developed countries like Indonesia. Settings and Design: This study was conducted in a regional general hospital setting. Methods and Material: We conducted a prospective cross-sectional study including 50 patients aged 6 months to 5 years old over 14 months. Patients were divided into 2 groups: Controls were the age and sex-matched febrile children without accompanying seizures, and the case group admitted with a first simple febrile seizure. Both case and control groups were normal in growth. To provide 95% confidence and 80% power in statistical analysis, a sample size of 25 for each group was calculated. Data including age, gender, body temperature, seizure characteristics, family history of febrile seizure, and laboratory findings consisting of hemoglobin, hematocrit, and mean corpuscular volume (MCV) were recorded. Anemia is defined as having hemoglobin level of less than 10.5 g/dl in children aged 6 months to 2 years old and less than 11.5 g/dl in 2 to 6-year-old patients.
Downloads
References
Aroor, S., Mundkur, S. C., Kumar, S., Handattu, K., & Samuel, P. C. (2024). Refractory microcytic hypochromic anemia with type I diabetes mellitus and reversible cardiac haemochromatosis in congenital hypotransferrinemia. Pediatric Hematology Oncology Journal, 9(1), 37-39. https://doi.org/10.1016/j.phoj.2023.12.008
Aziz, K. T., Ahmed, N., & Nagi, A. G. (2017). Iron deficiency anaemia as risk factor for simple febrile seizures: a case control study. Journal of Ayub Medical College Abbottabad, 29(2), 316-319.
Baumann, R. J., & Duffner, P. K. (2000). Treatment of children with simple febrile seizures: the AAP practice parameter. Pediatric neurology, 23(1), 11-17. https://doi.org/10.1016/S0887-8994(00)00148-X
Chaudhary, B. R., Malla, K. K., & Gaire, B. (2021). Association of iron deficiency anemia with febrile seizure in children in a tertiary care hospital.
Chung, B., & Wong, V. (2007). Relationship between five common viruses and febrile seizure in children. Archives of disease in childhood, 92(7), 589-593.
Dutta, M., Bhise, M., Prashad, L., Chaurasia, H., & Debnath, P. (2020). Prevalence and risk factors of anemia among children 6–59 months in India: A multilevel analysis. Clinical Epidemiology and Global Health, 8(3), 868-878. https://doi.org/10.1016/j.cegh.2020.02.015
Eilbert, W., & Chan, C. (2022). Febrile seizures: A review. Journal of the American College of Emergency Physicians Open, 3(4), e12769.
Jang, H. N., Yoon, H. S., & Lee, E. H. (2019). Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC pediatrics, 19, 1-8.
Kimia, A. A., Bachur, R. G., Torres, A., & Harper, M. B. (2015). Febrile seizures: emergency medicine perspective. Current opinion in pediatrics, 27(3), 292-297.
Kubota, J., Higurashi, N., Hirano, D., Isono, H., Numata, H., Suzuki, T., ... & Hamano, S. I. (2020). Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures. Journal of the Neurological Sciences, 411, 116682. https://doi.org/10.1016/j.jns.2020.116682
Leung, A. K., Hon, K. L., & Leung, T. N. (2018). Febrile seizures: an overview. Drugs in context, 7.
Li, X., Lin, Y., Yao, G., & Wang, Y. (2018). The influence of vaccine on febrile seizure. Current Neuropharmacology, 16(1), 59-65.
Millichap, J. G., & Millichap, J. J. (2006). Role of viral infections in the etiology of febrile seizures. Pediatric neurology, 35(3), 165-172. https://doi.org/10.1016/j.pediatrneurol.2006.06.004
Pollitt, E. (2001). The developmental and probabilistic nature of the functional consequences of iron-deficiency anemia in children. The Journal of Nutrition, 131(2), 669S-675S. https://doi.org/10.1093/jn/131.2.669S
Sawires, R., Buttery, J., & Fahey, M. (2022). A review of febrile seizures: recent advances in understanding of febrile seizure pathophysiology and commonly implicated viral triggers. Frontiers in pediatrics, 9, 801321.
Shah, F., Kazi, T. G., Afridi, H. I., Baig, J. A., Khan, S., Kolachi, N. F., ... & Shah, A. Q. (2010). Environmental exposure of lead and iron deficit anemia in children age ranged 1–5 years: a cross sectional study. Science of the total environment, 408(22), 5325-5330. https://doi.org/10.1016/j.scitotenv.2010.07.091
Soindemi, C. M. A., Pesurnay, Y., Pinem, O., Utama, R. P., Yanti, L. C., & Argaheni, N. B. (2022). Relationship levels of knowledge, attitude, behavior, and school support in anemia students. International Journal of Health & Medical Sciences, 5(4), 286-293. https://doi.org/10.21744/ijhms.v5n4.1956
Sutarini, I. D. A. A. D., & Windiyanto, R. (2023). Relationship between Febrile Seizures and the Incidence of Microcytic Hypochromic Anemia in Children at Sanjiwani General Hospital, Gianyar, Indonesia. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 6(18), 2944-2947.
Tarhani, F., Nezami, A., Heidari, G., & Dalvand, N. (2022). Factors associated with febrile seizures among children. Annals of Medicine and Surgery, 75, 103360. https://doi.org/10.1016/j.amsu.2022.103360
Teran, C. G., Medows, M., Wong, S. H., Rodriguez, L., & Varghese, R. (2012). Febrile seizures: current role of the laboratory investigation and source of the fever in the diagnostic approach. Pediatric emergency care, 28(6), 493-497.
Thirupathi, A., & Chang, Y. Z. (2019). Brain iron metabolism and CNS diseases. Brain Iron Metabolism and CNS Diseases, 1-19.
Veisani, Y., Delpisheh, A., & Sayehmiri, K. (2013). Familial history and recurrence of febrile seizures; a systematic review and meta-analysis. Iranian Journal of Pediatrics, 23(4), 389.
Zareifar, S., Hosseinzadeh, H. R., & Cohan, N. (2012). Association between iron status and febrile seizures in children. Seizure, 21(8), 603-605. https://doi.org/10.1016/j.seizure.2012.06.010
Zhang, F., Yang, J., Wang, Y., Cai, M., Ouyang, J., & Li, J. (2023). TT@ MHA: A machine learning-based webpage tool for discriminating thalassemia trait from microcytic hypochromic anemia patients. Clinica Chimica Acta, 545, 117368. https://doi.org/10.1016/j.cca.2023.117368
Published
How to Cite
Issue
Section
Copyright (c) 2024 International journal of health & medical sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health & Medical Sciences (IJHMS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHMS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHMS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.