Atherosclerosis towards rat relating with high cholesterol feed

Authors

  • I Gusti Agung Dewi Sarihati Poltekkes Kemenkes Denpasar, Bali, Indonesia
  • Ketut Suastika University of Udayana, Indonesia
  • I Wayan Wita University of Udayana, Indonesia
  • I Nyoman Mantik Astawa University of Udayana, Indonesia
  • Anak Agung Ayu Mirah Adi University of Udayana, Indonesia

Keywords:

arteries hardening, atherosclerosis, high-cholesterol feed, rat aorta walls, standard feed

Abstract

Atherosclerosis or arteries hardening was a condition wherein occurred a plaque buildup in the arteries and often related to high-cholesterol foods. Aims: The research was intended to prove the high-cholesterol feed could increase the occurrence of atherosclerosis towards rat aorta walls. Methods: The Randomized Post-test Only Control Group Design was conducted in two groups of male Wistar rats 10-12 weeks old, weight from 140 to 150 grams. Each group consisted of 10 rats, one group was fed a standard feed and the other group was fed a high-cholesterol feed. Histopathological preparations were to use Hematoxylin-eosin staining (HE). The data were analyzed by computer, with ? 0.05. Results: Eighty percent of a rat who was fed a high-cholesterol feed was found a plaque in its aorta while the rat fed a standard feed only 10%. It was obtained a relationship between high cholesterol feed with the plaque formation in the rat's aortic wall (p 0.003). Conclusion: There was a relationship between the feed provisions of high-cholesterol with the occurrence of atherosclerosis towards rat aortic.

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Published

2017-03-31

How to Cite

Sarihati, I. G. A. D., Suastika, K., Wita, I. W., Astawa, I. N. M., & Adi, A. A. A. M. (2017). Atherosclerosis towards rat relating with high cholesterol feed. International Research Journal of Engineering, IT & Scientific Research, 3(2), 150–156. Retrieved from https://sloap.org/journals/index.php/irjeis/article/view/542

Issue

Vol. 3 No. 2: March 2017

Section

Research Articles
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