Current update on stroke ischemic management: Stem cell as emerging therapy

Andhika Tomy Permana; Nur Setiawan Suroto; Muhammad Arifin Parenrengi; Abdul Hafid Bajamal; Pudji Lestari; Asra Al Fauzi

doi:10.21744/ijhms.v5n1.1851

Authors

Andhika Tomy Permana Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Nur Setiawan Suroto Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Muhammad Arifin Parenrengi Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Abdul Hafid Bajamal Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Pudji Lestari Department of Public Health Science and Preventive Medicine, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia
Asra Al Fauzi
asraalfauzi@gmail.com
Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia

Keywords:

clinical trial, emerging therapy, neuroregeneration, stem cell, stroke ischemic

Abstract

Stroke is one of the most important causes of morbidity and mortality worldwide, with survivors subjected to long-term disability. Stroke is classified as ischemic and hemorrhagic. 87 % of strokes are classified as ischemic. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by an ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons to improve neurological recovery. Further understanding of the mechanisms by which the stem cells exert their beneficial effect could potentially revolutionize the field. The next decade of stem cell research in stroke needs to focus on. Although still in need of exploration, stem cell treatments for stroke may offer ways to protect and replace neurons to improve outcomes for stroke patients.

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